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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

每个月,梦工厂(DreamWorks)的员工都能收到价值25美元的消费券,可在位于格伦代尔和雷德伍德城园区的“梦工厂打印中心”消费。由于只收取原材料费用,该工作室能以低价向员工提供各类服务,例如在贺卡上打印照片、制作个性化日历等。
尽管詹姆斯和费德勒在工资和薪水上要少一些(相比于C罗和梅西),但是这两人去年的代言费是最高的,其中17次大满贯得主费德勒去年代言收入达到了4100万英镑。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

In 2016, we've seen a whole lot of new gadgets join the Internet of Things (unfortunately, we've also seen them harnessed by hackers to bring downhuge swaths of the internet). From appliances to clothing, companies really want to sell you the tech that'll make your life "smarter," but sometimes it just makes it slower and dumber. Let's look back on some of the most ridiculous and useless internet-connected gadgets that were produced in the past 12 months.
A mother has written a letter in defence of her 14-year-old son who is facing a lawsuit over video game cheats in the US.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

报告还发现,在“智力资本和创新”及“技术成熟度”等指标方面排名较高的城市综合排名也很高,这很明确地表明,技术上先进的城市更有可能成为“机遇城市”。

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

WHAT: A Greek Revival with four bedrooms and four and a half bathrooms

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

加快推进国企国资改革。
SplashData发布这份榜单是为了鼓励大家使用复杂的密码。摩根·斯兰还说道:“和往常一样,我们还是希望通过了解使用简单密码存在很大风险,大家能设立比较严谨的密码来保护自己,并在不同的网站上使用不同的密码。”
张国立将主持2014年春晚
贴近大自然。在桌上摆放一盆植物是振奋自己的一个好办法。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

Brian Kendrella, president of New York-based Stack's Bowers Galleries, says the auction drew half a dozen bidders from six countries. The winning bidder Thursday was an individual collector from Asia who asked to remain anonymous.
A fourth terminal has just been completed and is due to open in the second half of 2017.
开发商:Remedy Entertainment、Microsoft Studios
清华大学在计算机科学和工程学两个学科中排名居首。这所中国院校今年取代了麻省理工学院,成为计算机科学最强学府。

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

日本总体排名第五,是亚洲表现最优异的国家。“原动力”排名第五,“前瞻性”排名第一。

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

Neshama Spielman, from Jerusalem, found the artifact four years ago at a dig organized by the City of David and the Temple Mount Sifting Project, which works to examine tons of dirt removed without archaeological supervision from the Temple Mount by the Muslim Waqf. Details of the find and its identification, however, have only now been revealed. Spielman, who is aged 12, was just 8 when she made the find.

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

In the field of the best 85 business schools in Europe, HEC Paris remains in second place behind LBS, while Insead, the international school based in Fontainebleau, France, climbs two places to third.
China's movie box office revenue rose 13.45 percent in 2017 to more than 55.9 billion yuan (8.6 billion U.S. dollars), with domestic films contributing 53.84 percent to the market, according to the State Administration of Press, Publication, Radio, Film and Television.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

Succeeding as an entrepreneur takes hard work and persistence because, unfortunately, there is no business-startup fairy who magically bestows success on small businesses and their owners.
After Google and Apple, are Amazon and Microsoft.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

Songs (Ping An, Xu Yina and Apusasa)
投资者也关注到了本田的这一困境。尽管在席卷全球的金融危机中,本田是全球少数几家能独善其身、避免严重亏损的汽车厂商之一,但在过去几年中,其普通股股价下跌了17.2%,而同期日经225指数却上涨了7.4%,丰田汽车的股价也上涨了19.5%。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

adj. 代理的,副的
考虑到波士顿咨询集团(Boston Consulting Group)管理合伙人理查德莱塞(Richard Lesser)的第二任期将于10月结束,该公司可能也将引来变化。然而,由于该公司拒绝就其选举流程及领导人最多可以有几个任期置评,莱塞的未来尚不明确。
A cheery New Year hold lots of happiness for you!给你特别的祝福,愿新年带给你无边的幸福、如意。
在赛场上,绰号Baby的天才逃亡车手(安塞尔?埃尔格特饰)依靠专属的音乐节奏开车而独占鳌头。与梦中女神(莉莉?詹姆斯饰)邂逅之后,Baby看到了希望,想与以往不堪的生活断个干干净净。Baby被迫为黑社会老大(凯文?史派西饰)干活,在派给他的最后一单中,危机一触即发。面前是巨大的挑战,对他的生活、爱人和自由来说,形势都岌岌可危……

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

Her piece, titled “Back to Mother Nature," depicts an elaborate water-cleaning machine. Zhang worked with a team of artists at Google to animate her drawing.

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

年龄:56岁
Hunger Games star Jennifer Lawrence on Tuesday topped a Forbes magazine list of the world’s highest-paid actress for the second straight year, earning some $46 million, followed by Melissa McCarthy.

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
From the themed collection: 建材家居企业半年报“亮红灯”
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

It is based on a survey of business schools and another of their alumni who graduated in 2013.

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

李说,记者职业排名靠后已经有一段时间了(去年在200个职业中排名第196位)。他说,这次被挤到最后一位很可能是因为有些情况更糟了,如职业前景变差、平均薪资继续下滑、工作时间持续增加等,而且这些因素也让记者的压力更大。

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

我花钱太多了吗?过度消费会导致压力、混乱以及财政并发症。这也可能会随着时间的流逝变为一种危险的习惯。储蓄是一个非常棒的办法,万一遇到紧急情况,你极有可能为你之前的储蓄而感到欣慰。
adj. 反对的,敌对的 v. 和 ... 起冲突,反抗
They will get more creative in 2018, including on non-cash benefits. Bank of America, for example, has just introduced a programme allowing employees of the global banking and markets unit to take a sabbatical — on full pay — for up to six weeks in a year. There are conditions: people must have been with the bank for at least a decade, and can request the time once every five years, to a maximum of three. But in a memo circulated this week, seen by the Financial Times, chief operating officer Tom Montag urged eligible employees to consider it.
The December budget deal was hardly the kind of confidence-boosting agreement Washington has been debating for years. But at least it hit the pause button on the serial brinkmanship that threatened to derail the recovery each of the past three years.

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

Mark Williams, chief Asia economist at Capital Economics, adds: “We expect that the performance of EM exports will continue to improve in 2017, with export values rising modestly in year-on-year terms.”
有些行业将会比其他的复苏得快一些。像建筑,制造这样的行业可以马上就开始招聘了。然而,零售,旅游,医疗这些依靠客户消费的行业则可能是复苏得最慢的。
ZnS#k]Z047gSW1juv]
大师级别的老式、线性的动作电影拍摄,充满污秽、朋克、反乌托邦的澳大利亚式幽默。也是最近除玛格丽特·阿斯特伍德(Margaret Atwood)的小说之外,最好的生态-女权-社会主义作品。
Thor: Ragnarok was so much funnier than you could ever expect it to be, and it's all thanks to the genius of Jeff Goldbloom combined with the genius of Taika Waititi—the latter of whom both directed the movie AND played a extremely earnest dude made out of rocks.

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

Gross National Happiness
第九步 每天,告诉全世界“别BB了”,其实这样蛮圈粉的

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

单词virtue 联想记忆:

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

主流网络游戏仍然是大型多人在线角色扮演游戏 (MMORPG)。报告说,今年10月,中国最热门的10款网络游戏中有6款都属于大型多人在线角色扮演游戏。动视暴雪(Activision Blizzard)开发的《魔兽世界》(World of Warcraft)在注册用户和最高同时在线人数方面仍然排名榜首。但报告指出,目前围绕着这款游戏大陆运营权的政府监管纷争可能会给《魔兽世界》带来负面影响。网易公司目前持有《魔兽世界》的中国大陆独家运营权。

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
From the themed collection: 天津爆炸:美克等家居企业受损
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

Casual games--simple games such as card games--take second place with three ranked among the top 10 game list, while Web page games--such as Tencents' QQ games--are emerging as a new growth area. According to the report, by the end of Octover 2009, there were 1.54 million users playing the top five Web page games, with each user playing for an average of 30 minutes a day.
But many others cities that have featured prominently in recent months remained relatively undaunted by the new popularity of purchasing curbs, as prices remained substantially elevated from a year earlier.
谢琳 伍德蕾
不断上演的进球大战正是本届世界杯精彩绝伦之处。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

Taylor Swift and Katy Perry opted for bedazzled5 dresses in very different styles. Taylor went for a more old Hollywood, glamorous Grecian style that exposed her back and statuesque6 figure, while Katy rocked a shorter, spunkier look that exposed a little of everything.
《善地》
旅行枕
n. 日历,月历,日程表

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

据Birinyi收集的数据,下面是今年迄今已经获得授权的5大回购。
4=true

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

Wade was probably a little easier to stop back in high school before he had filled into his 6'4'' frame that makes him so unstoppable today.
以下四个因素应该会对2013年的就业复苏起到推动作用:[qh]
Fortunately, the rules are changing. The proposal of China's Central Economic Conference in early December to give rural residents permanent urban residency sent a strong signal. Premier Wen Jiabao's call in late December for the reform of the household registration system will surely speed up the process.
10. 注意自己的心态。
['disk?:s,dis'k?:s]

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

The unemployment rate probably won't fall quite as rapidly in 2015, according to economists, especially if more people enter the labor force because jobs are easier to find. Yet another large spate of hiring similar to the gain in 2014 would make the low unemployment rate more believable.
There are a wide range of low-cost flights to Russia and transportation in the country is also easy with the Trans-Siberian Railway.
近几十年来,很少有年份像2014年那样一开始就充满那么多的悲观情绪。对2014年的预测贯穿了一个主题,即这一年看起来与1914年相似得让人害怕。大多数学者的预测都是悲观和令人沮丧的,尤其是对于东亚。然而,虽然发生了许多可怕的事件——从马航MH17航班在乌克兰坠落,到尼日利亚数百女学生被绑架,以及“伊拉克和黎凡特伊斯兰国”(Isis)的崛起——但我们避免了全面的世界大战。现在,2014年已结束,没有重现1914年的悲剧。探究为什么这些学者预测错了(特别是他们认为亚洲存在冲突可能性的想法)或许是明智的。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

repertoire
The December budget deal was hardly the kind of confidence-boosting agreement Washington has been debating for years. But at least it hit the pause button on the serial brinkmanship that threatened to derail the recovery each of the past three years.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

有了这个支架,吊床随处都能搭。可以搭在水上、雪上、公路上。
Annual prices had been rising as much as 9.6 per cent at the start of this year but they've cooled since then as the economy slows and many mid-sized Chinese cities suffer from a glut of apartments.
To tackle the problems, the report suggests that e-commerce laws should be developed as soon as possible. It also calls for the establishment of an online credit system to strengthen the discipline of the e-commerce industry.

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

凯文·史派西、摩根·弗里曼这样的明星也难逃一劫,被指控性侵演员,积极的网友在网上用标签分享各自的心路历程。
扎实推进新型城镇化。
这个夏天,诺埃尔将成为受限制自由球员,考虑到他公认的防守能力、未开发的潜力和乐透秀身份,他期望得到一份慷慨的补偿合同,即使他的职业生涯上场时间还不足5000分钟。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

From the themed collection: 不动产登记跑出“孝感速度”
Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

Others have come up with some, um, creative ways to say sayonara. When staffing firm OfficeTeam asked about 600 U.S. human resources managers to describe the weirdest ways they’ve seen or heard people resign lately, here’s what they said:

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

“加之相比创业,高校更注重培养学生的创新意识。这也是大学生创业意向如此低的另一个原因。”

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

深入推进“互联网+”行动和国家大数据战略;
200亿美元的数额会让任何一位投资垂涎,但这笔钱需要在回购和派息之间进行分配。与2014年其他公司宣布的股票回购相比,这笔钱只能算是零花钱。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

埃尔多安对荷兰的声讨升级发生在这样一个时刻:上周末,在荷兰官员禁止土耳其部长在荷兰国内的土耳其社区拉票之后,安卡拉与海牙之间开始了一场针锋相对的相互报复。
More than 110 new and returning series made the shortlist for this roundup before being whittled down to the 20 that appear here. (And that’s without the HBO shows “True Detective,” which is being moved to later in the year, and “Game of Thrones,” “Veep” and “Silicon Valley,” whose April premiere dates haven’t been announced.) From a “Breaking Bad” spinoff, to the return of “Broadchurch,” to the final season of “Justified,” the winter is high season for the serious TV watcher.
梅瑟威一场拳赛的要价可以高达7000万英镑,但是他去年的收入只排在榜单上位居第16位。去年梅瑟威的拳赛收入达到了2000万英镑,此外他的服装品牌TMT(The Money Team)也给他贡献了500万英镑。
随着美国电子商务交易接近零售总额的10%,越来越多的商家开始寻找既好用又能帮他们快速卖出商品的电商平台。

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

当瑞秋·布鲁姆听闻自己赢得喜剧类电视最佳女主角奖项时,喜极而泣。亚马逊节目《丛林中的莫扎特》也意外斩获最佳剧集奖项。
“今年榜单有趣的地方之一是,尽管网站都开始实行更严的密码设定政策,位数少的密码仍出现在今年的榜单上。”

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
From the themed collection: 2017年橱柜产品发展趋势
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

['vai?r?s]
Investigators have arrested one youth and one 18-year-old in connection to the July 9th shooting.

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
From the themed collection: 泛家居行业金融新工具即将面世
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

2. Lumberjack

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

"电梯外面很多人,有我的老师,别的家长们,他们看起来都非常焦急,"孙轶潇在获救后表示。
She said: 'Bobbi's like a little Beyonce, a little madam really.'
不错,2014年完全是一场灾难,只等着引爆。在《年内股市崩盘的概率有多大?》(Doomsday poll: 87% risk of stock crash by year-end)一文中,我们分析了今年年初以来的10大崩盘征兆。之后,我们又不断发现了更多新的妖魔。它们有如嘀嗒作响的定时炸弹,来自国会、最高法院、性问题、碳排放、石油巨头、国家安全局(NSA)、国税局(IRS)、茶党式财政紧缩。接踵而至,让人无法招架。
Song “The Sacred Land” (Sun Nan)

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

check
“在三个月里,我在我的三个女儿身上总共花费了5000英镑。有一件裙子花了我两百美元,她只穿过两次,就长高了、不合身了。——不过我不打算节制开支。”

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

distract
新兴市场需求减弱使2015年成为全球金融危机爆发以来世界贸易最糟糕的一年,凸显出对于全球经济健康的担忧加深。
Plans to open 20,000 specialist football schools in 2017, aimed at training young players and cultivating talent, are part of the government's latest plan to advance China's ability to compete on the global pitch.

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

It also has a lot of inexpensive museums, cheap vintage trams and beautiful pebbly beaches. Day trips to vineyards are easy to arrange.
Carry out deleveraging in an active and prudent way.
他们先在伦敦中心广场上开了个熊猫聚会,接着来到特拉法加广场打太极。这一切都是第一届"感受熊猫"周的特别活动。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
From the themed collection: 2018房改之年: 房价趋稳 房企趋大
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

前十强还包括排第二的卢森堡大学,第四的洛桑联邦理工学院,第五的日内瓦大学,第七的苏黎世联邦理工学院,第八的圣加仑大学,第九的新加坡国立大学和第十的帝国理工学院(伦敦大学)。
我只是忍不住希望,随着《广告狂人》的终结,一个时尚阶段也能终结,在这个阶段,设计师们被困于过去的时代,几乎窒息——至少是困在20世纪60年代(不要忘了,60年代初与50年代末非常相似)至70年代初。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

他表示那个时候的人有另外一种浪漫,人们没有电脑,所以交流都是通过信件,这样其实更浪漫。
Hurun’s China Rich List, which tracks more than 2,000 private entrepreneurs with a net worth of $300m or higher, added 179 names to its roster this year.
《深红报》称,此次被取消入学资格的学生所在的私人脸书群组名为“哈佛饥渴猥琐资产阶级少年”。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

《患难与共》(Togetherness),HBO,1月11日播出。HBO台的周日晚间喜剧组合中已经有了20出头的纽约女人(《都市女孩》[Girls]第四季第一集将在同一天晚上播出),还有快到30岁的旧金山男同性恋(《寻》[Looking]也在当天开播第二季)。现在又来了30多岁的洛杉矶异性恋者们。这部有点阴郁的半小时喜剧来自杰伊(Jay)和马克·杜普拉斯(Mark Duplass),兄弟俩曾经合拍过《肥大的椅子》(The Puffy Chair)和《纸袋头》(Baghead)等诡异的电影。马克·杜普拉斯和梅兰妮·林斯基(Melanie Lynskey)饰演一对夫妻,和杜普拉斯最好的朋友(史蒂夫·齐西斯[Steve Zissis]饰演)与林斯基的姊妹(阿曼达·皮特[Amanda Peet]饰)合住一栋房子。
I can't stop thinking that these children are my age, that it makes a tremendous difference where you are born, that I could be one of those children living in the Favellas of Rio; I could be a child starving in Somalia; a victim of war in the Middle East or a beggar in India. 我永远不能忘记这些和我同龄的孩子,当你出生的时候,他和我们真的很不相同,我也许生活在贫民窟,也可能是终日饿着肚子的小孩,也可能是中东战争的牺牲品,或者印度的小乞丐。

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
From the themed collection: 揭秘:红木家具很有投资价值!
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

2. Will China's stock market climb back to 6,000 points?
adj. 复杂的,复合的,合成的
2016年,9个省级地区的GDP超过3万亿元,比上一年增加3个;25个省级地区的GDP突破1万亿元,与上一年持平。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

在“有工作经验要求”项目排行榜上,伦敦商学院的学生在毕业3年后平均薪资最高,为13万美元左右,目标实现率也最高(87%)。该项目还在就业成功率以及国际课程经验方面拔得头筹。该学院学生在国际流动性和职业进展方面排名第二。

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

第三个枪手,Amedy Coulibaly,在周五袭击了一家犹太超市,没有出国接受过培训,Valls说。
The show was a potent reminder that the sexual revolution and women entering the work force and the rise of consumerism and the Age of Aquarius (all that) had a dark side, and claimed their own victims. That’s part of why it was such a powerful show.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
From the themed collection: 福州拟投15亿元建装饰建材产业园
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

headway
自2007年4月以来,全球最具价值品牌100强的品牌价值增长106%。同期标准普尔500指数(S&P 500)和MSCI明晟全球指数(MSCI world index)分别上涨61%和21%。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

East Asia's cinephiles won't have a local favorite to cheer during this year's foreign-language Academy Awards race after the Taiwan epic 'Warr
在这两个新指标方面,英国商学院的表现都优于法国商学院。在职业发展方面表现最好的英国商学院——华威商学院(Warwick Business School)在这一指标的总体排名中位居第二,高于法国在这方面表现最好的巴黎高等商学院(HEC Paris) 30个名次。在毕业后首份工作薪资与当下薪资比较方面,英国商学院校友的薪资增幅更大,为62%,法国商学院校友的薪资增幅为45%。然而,英国商学院校友的平均薪资仍低于与法国商学院校友,分别为5.5万美元和6.4万美元。

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

如果您以前听过这句话,那就当我没说:一家未经考验,没有任何收入的社交媒体公司获得一个令人晕眩的的报价。不顾所有人的建议,那位自命不凡,二十出头的CEO拒绝出售。与此同时,不知从哪儿冒出来的竞争对手突然发起诉讼,言之凿凿地声称他们的创意被窃取了。
Bingo! In fewer than 20 words it combined five previous years’ winners, only to say nothing at all. With a heavy heart, I award eBay my overall Golden Flannel Award for 2016.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

Transport Ministry spokesman Xu Chengguang told a news conference that no further signs of life had been found and the chance of finding anyone else alive was "very slim."

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

Morgan Stanley’s Jonas believes the Model X will sell more based on features like its upgraded infotainment system unique “falcon-wing” back-seat doors than fuel economy and he will be disappointed if the Model X doesn’t win every major car of the year award. He isn’t alone. So will Elon Musk and a whole lot of Tesla investors who pray that the momentum behind this amazing stock keeps building.
Investigators have arrested one youth and one 18-year-old in connection to the July 9th shooting death, which occurred inside a Jamestown Cres. home.
《危险!》(Jeopardy!):这个游戏节目今年已播出50年(1964年3月30日首播),它证明自己不仅能难住观众,而且能令他们感到意外。不仅是因为主持人亚历克斯·特里贝克(Alex Trebek)留起了胡子(之前13年他都是把胡子剃得干干净净),而且是因为仍有些选手表明自己能刺激观众。今年刺激观众的是亚瑟·朱(Arthur Chu),他采用闪电战式的答题方式,在网上引起一片哗然。他的策略令人兴奋,当然也很奏效:他在锦标赛中夺得第二名(友善的本·因格拉姆[Ben Ingram]最后得了第一)。
昨日,中国四大国有银行中的两家——中国工商银行(ICBC)和中国银行(BoC)——均报告称,2015年全年净利润增长低于2%。

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

There were also shows that didn’t live up to early expectations but still had traction, most notably “The Affair,” on Showtime, which began as a Hamptons film noir and instead turned into a French art film. The crime may not be commensurate with the series’s punishingly slow pace and “Rashomon"-like storytelling, but the series picked up momentum — and suspense — in the final episodes.

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

“As the economy enters the ‘new normal’, the industry sector faces increased downward pressures, unreasonable structures and weak innovation capability,” Mao Weiming, vice-minister at the Ministry of Industry and Information Technology, said at a press conference.
获奖者:林赛·罗韩
普斯·格洛(Pussy Galore)在本书中回归,这也是首次有邦女郎在邦德身边昙花一现后,拥有了自己的故事线。

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

4.You Don't Like Most of Your Coworkers
ceremony

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

credit
Moonlight, an evocative coming of age story about a young gay black man, won best picture at the 2017 Oscars but was almost denied its victory in chaotic scenes when the award was mistakenly given to La La Land.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

The issue has also hit Beijing’s efforts to secure market economy status in the WTO, which it claims it will be entitled to automatically on December’s 15th anniversary of it joining. If China obtains that status it could affect the ability of the US and others to bring anti-dumping cases, as it would remove their ability to use prices in third countries for comparison.

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

Harvard University topped the rankings for the 16th consecutive year, and Stanford University and University of Cambridge remained in second and third place, respectively.
D1t]!J^-6h=kwFS)I
The first is to view Asia as a market that has proved resistant to rapid development and will require significant structural and regulatory change before taking off. The second sees the possibility of sudden upside surprise.

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

都不是。1772年,一场空前的危机击中了阿姆斯特丹:一家受人尊敬的荷兰投资银团对不列颠东印度公司(British East India Company)股票的投资变成了一场灾难。
The auction house says seven records in all were set at the Geneva auction including the highest amount ever paid for a yellow diamond - $16.3 million for the 100.09-carat Graff Vivid Yellow diamond ring.
2016年奥运会和2014年足球世界杯主办城市里约打败了希腊,成为搜索次数最多的旅游目的地。
普京对俄罗斯经济做出积极评价。他说,经济已渡过危机,至少渡过了危机的高峰。

Graphical abstract: Length-scale dependence of protein hydration-shell density
From the themed collection: 广东保障城市停车场建设用地
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

China's mass entrepreneurship and innovation initiative has a strong vitality.
Tencent has been helped by agreements to pre-install software with Chinese handset makers who sold increasing numbers of handsets abroad in recent years, particularly in emerging markets, according to Mr. Wang.

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

伯利兹城靠近墨西哥和加勒比海,各处都是露天的街头小吃摊,为游客们提供了很多较实惠的用餐选择。
根据1894家上市公司公布的2016年财务年报的数据显示,金融和地产业的高管薪酬最高。
?The Aston Martin doesn't hurt. Not at all. Neither does dropping tons of cash at exotic casinos -- throwing money around makes men more attractive to women who are interested in flings. And, like Bond, men who gamble with women around are better at it.

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
156 items - Showing page 1 of 3

About this collection

enter在中间+tain拿住+ment→在[工作]中间拿→娱乐,款待
n. 运输、运输工具;(常用复数)强烈的情绪(狂喜或狂怒

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