Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
200911/88512.shtmlA 1936 Nobel Peace Prize discovered at a South American pawn shop has been sold at auction in Baltimore for $1.16 million.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Perhaps the more interesting question is what drove Yahoo! to shell out that reported $30 million for a single app. To be sure, Summly's text-compression abilities dovetail nicely with Yahoo!'s new focus on mobile utilities. Along with Yahoo!'s $1.1 billion purchase of the blogging service Tumblr and the launch of an acclaimed new weather app, the Summly move marks a commitment to owning the tiny real estate of the smartphone screen-and serving advertising to the youthful eyeballs that tend to gravitate to mobile devices.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
《为奴十二年》导演史蒂夫?麦奎因(Steve McQueen)在登台领奖时说：我有点吓到了。然后他微微耸肩，引用片中福音歌曲的歌词，说了句“翻涌吧，约旦河，翻涌吧”("Roll, Jordan, roll")。
The cemetery was found in the city of Kucha, which is located in present-day northwest China. Ten tombs were excavated, seven of which turned out to be large brick structures.
Farewell to Cassini
Trends and targets in antiviral phototherapy
For Maddie Ziegler, from Pennsylvania, life couldn't be more different.
Total migrant worker earnings are estimated to be $3 trillion annually, of which approximately 85 percent remains in the host countries. The money migrants send home averages less than one percent of their host country's gross domestic product, IFAD said.
Despite car and truck sales that motored past 16 million for the first time since 2007, recalls dominated the news for most of the year. General Motors GM 1.42% held center stage, dealing with cascading revelations about faulty ignition switches and recalling millions of vehicles. While GM opted for something approaching full disclosure of its missteps , publishing an report into company-wide fumbles, Japanese airbag maker Tanaka chose to stonewall. It left any remedies up to its beleaguered customers, notably Honda and Toyota. They are the ones who deal with the fallout of exploding safety devices that fatally fired shrapnel throughout the passenger compartment.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Graduates of Tsinghua University make more money, on average, than those from any other college in China, results of a recent survey showed.
ACE2 as a potential therapeutic target for pandemic COVID-19
节目19 歌曲《一辈子朋友》，杨坤 张靓颖
Burgeoning crude supply is liable to drive prices lower in 2014 after a run of years when emerging markets supported demand, as shifting dynamics continue to change the oil landscape.
Diagnostic technologies for COVID-19: a review
Like many child stars, Maddie speaks of being old before her time.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Gary Oldman on blistering form as Winston Churchill.
I will be yours forever!我永远属于你！
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
"Their political leanings are even affecting how they experience weather, which is pretty fascinating," said Cox.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
The "Quarterly Journal of Experimental Psychology" published a study in early 2016 entitled, "The drawing effect: Evidence for reliable and robust memory benefits in free recall." While the title seems a bit long and complex, the study actually demonstrated a very simple idea. Drawing words in picture form helps people make better and stronger memories. The authors of the study created simple tasks where a participant would first draw a simple word, like a common piece of fruit. Later, the authors of the study would ask the participants to recall the words they drew. Other participants in the study were given different tasks like repeating the given word aloud a certain number of times or actually writing the word down. The researchers found that participants who drew doodles of the words they needed to recall fared much better than other participants.
The growth has laid a solid foundation for the development of the film industry in China in the future, the experts added.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
8. Victoria and Abdul
She suffered anorexia while in an abusive relationship after she arrived in Los Angeles.
Influenza neuraminidase: A druggable target for natural products
7. Big anti-corruptionprograms will be accelerated. We expect to see increased prosecutions,from approximately 140,000 per annum today to more than 200,000 in 2014. Thisaggressive push for integrity and accountability will set the country on astrong new course. Success will become much more about what you know ratherthan who you know.
What’s in a shade? If you are Pantone, the “color authority” and the dominant color trend forecaster, and you get to choose a “color of the year” every year, potentially a lot. It could include determining fashion’s direction (these are the hues that inform the fabrics that get bought by designers that get made into your clothes), influencing interiors, and even affecting how food appears. Still, I don’t think I’ve ever seen quite so much political and philosophical import attached to a color decision as I have for the 2016 “Color of the Year.”
The Big Bang Theory is not short on geniuses. Not only is the show about highly intelligent scientists, but cast member Mayim Bialik has a Ph.D. in Neuroscience. So it should come as no surprise that the cast would want to show off their intelligence and attention to detail. In Sheldon and Leonard's apartment, there's a large white board. The two roommates use the board frequently for everything from actual work that Leonard or Sheldon has brought home, or to decide whether to eat before or after the new Spider-Man movie.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Given the Raptors' existing personnel, the Ibaka/Tucker additions qualify as massive defensive upgrades, giving coach Dwane Casey the tools he will need to grind out postseason wins if Lowry and DeMar DeRozan see their scoring efficiency dip as it has in years past.
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Others will look for ways to use tech to help people spend less time online. Tristan Harris, a former Google employee, is building a following for his Time Well Spent movement, tackling what it describes as the “digital attention crisis” by encouraging designers to understand the subtle psychological forces they control. Tim Kendall, formerly of Pinterest and Facebook, is reported by Recode to have plans for a start-up focused on fighting device addictions.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Song “The Sacred Land” (Sun Nan)
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Literally in the last seconds of the match the Dutch scored its second equalizer. During stoppage time China scored a third goal which won them the Robot World Cup Soccer 2013.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
10. How to find IP address
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
It has now entered the top 20 for the first time.
"China is Australia's most valuable tourism market, with the potential to be worth more than $13 billion by 2020."
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
In contrast to last year when the vast majority of economists expected the ECB to launch full-scale quantitative easing, just under half of the 33 respondents thought the ECB would do nothing this year. The rest said the ECB would expand QE or cut interest rates, although some of those who expected more easing stressed that the central bank was unlikely to radically reshape its existing policy response.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
5.3-D Printed Ears
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Polls indicate that the Dutch election will be extremely tight. Mr Rutte’s centre-right VVD sits atop most polls, just 3 percentage points ahead of the PVV. Most polls show a large percentage of voters remain undecided.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
“These kinds of questions are really front and center, even though they’re not necessarily verbalized.”
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
根据荷兰经济政策研究局(Netherlands Bureau for Economic Policy Analysis)发布的《世界贸易监测》(World Trade Monitor)报告，以美元计算，去年跨越国际边境的商品总价值下降了13.8%，是自2009年以来的首次萎缩。这一暴跌很大程度上源于中国和其他新兴经济体的放缓。
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
McGowan has also hit out at Meryl Streep, saying that it is 'literally impossible' the actress knew nothing of Weinstein's sexual proclivities until last autumn.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Misrepresenting your credentials or intentionally plagiarizing, lying on time sheets or billable hours, misusing expense accounts or abusing company credit cards, stealing the kudos for a co-workers' accomplishments, or otherwise robbing your employers blind can all cost you your job.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
室内环境：这栋砖砌结构、灰泥粉饰并铺着瓷砖屋顶的两层楼房屋由Dorr & Dorr公司设计，于1916年完工，近15年内曾经翻修。该房屋采用了半牧场、半工匠艺术的设计风格，运用了简洁的线条、开敞式空间、典雅的木制品和彩色玻璃等设计。翻修工程由明尼阿波利斯市Sala建筑公司的约瑟夫·麦茨勒(Joseph Metzler)完成。
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Many believe the population is no longer a major threat to China's resources and environment. Instead, China's population challenges have shifted to low birth rates, an aging society and a widening gender imbalance. China has already experienced a shortage of skilled workers in places like the Pearl River Delta, so it might not be long before we see major reforms.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
The gig economy
批评人士一直急于指出，库克对新产品开发的参与度不如他前任那样高，而且当他走上舞台介绍新品时，也无法引起同样的兴奋。但库克知道自己的短处，他从健身和时尚界招揽人才，组建了一支新团队，其中包括前博柏利(Burberry)首席执行官安杰拉?阿伦茨(Angela Ahrendts)，以及工业设计师马克?纽森(Marc Newson)。
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
In 1995 Dutch troops serving as UN peacekeepers failed to prevent Bosnian Serb forces murdering 8,000 Muslim men and boys in the town of Srebrenica in eastern Bosnia.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
9. You've been avoiding your boss。
1. Newspaper reporter
There are, of course, complicated contours to 2016’s unusual politics. In Britain, immigrants from South Asia voted heavily to leave the European Union, citing hopes that curtailing European migration might open space for more people from Asia. In the United States, frustration with and alienation from status quo politics have helped drive Mr. Trump’s rise.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
You can read the full list of stories, but here are the top five:
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A study published in the journal "Clinical Psychological Science" in 2012 showcased the power of self-imagination, which showed the technique could help people with impaired memories, as well as individuals with no memory problems. As with other studies of human memory, the scientists asked participants to remember a list of words related to certain personality traits. The participants were then asked to use a specific strategy to help them recall the words. For example, some participants were asked to remember one personality trait by thinking of a second word that rhymed with the trait. Other participants were asked to remember the definition of the trait while others were asked to engage in "self-referential processing" where they would think about the trait in a personal, self-reflective way.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
The reading is just below economists' forecasts but it's not altogether surprising. When the People's Bank of China unexpectedly cut interest rates last month, some analysts said the move was likely a pre-emptive one and that a spate of weak data was likely ahead. Well, here it is.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
9. Add Personality
A facile assay for rapid detection of COVID-19 antibodies
The University of Tokyo (22nd) and Kyoto University (35th) have maintained their positions as the leading universities in Asia.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
To SKN Company in Russia for exploding old Russian ammunition and creating diamonds. Now that's recycling!
Oh Carmelo, I wish you still had your high school mini-fro. It was absolutely epic.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
The predictions of no further action in an annual Financial Times poll of eurozone analysts came despite Mr Draghi’s attempts to convince markets that the ECB remained primed to act should inflation and growth across the single currency area continue to disappoint.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Rafael Corrales, a partner at Charles River Ventures, believes that the growth in a wide range of fields—from academia to infrastructure to policy—is a sign that 2014 was the biggest year bitcoin has had yet, despite its volatility. “In the short-term, that’s an easy knock from people who don’t understand or believe it can be something,” he says. “It’s the easiest thing for them to go after. In that transition stage, you’re going to have extreme volatility, so looking at its value over one year is kind of silly.” As for occasional hacks, he adds, “There are going to be bumps in the short term, but they’ll be solved sooner than later. And these things are being addressed by a huge community of people. So you have to be really excited, despite small bumps.”
?Bond is supremely confident. This makes him sexy. It also makes him great at his job; being overconfident often gives better results than being objective and rational. (We'd all be better off moderately overconfident.) Neither men or women prefer modest guys. Bond has the personality of a trained man of action: SWAT team members differed from the average person by being extremely confident ("self-deceptive enhancement"), more emotionally stable and more resilient.
But top managers at companies in the fields of scientific research and technology services saw their pay decrease by 4.2%.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
The awards returned Ms. Lawrence, a winner last year for Russell's 'Silver Linings Playbook,' to the stage for an acceptance speech-something she said was no easier a year later.
The school is also second for its international course experience. More than four in five of its latest graduating cohort went on an internship abroad and over half studied in another country for more than a month.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Meme-sharing Facebook groups have become a new college tradition, Mic reported last week, with students across the country trading inside jokes and fighting battles with rival universities via screenshot and caption.
Yes, 2014 is an absolute total disaster just waiting to ignite. In 'Doomsday poll: 87% risk of stock crash by year-end' we analyzed 10 major crash warnings since early this year. Since then, more incoming bogies raced across our radar screen. Ticking time bombs from Congress, the Supreme Court, sex, carbon emissions, Big Oil, NSA, IRS, Tea Party austerity. Relentless. Mind-numbing.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
The awards returned Ms. Lawrence, a winner last year for Russell's 'Silver Linings Playbook,' to the stage for an acceptance speech-something she said was no easier a year later.
Anti-HIV drug repurposing against SARS-CoV-2
Length-scale dependence of protein hydration-shell density
One of the things that makes Guardians such a great superhero franchise is its sense of humor—which is full of self-deprecation and sarcasm. It's not like you're going to watch this movie and laugh your way through it, but you'll at least have some moments of "ha ha, Groot," and "lolololol Chris Pratt."
As for bitcoin in the mainstream banking system? “We are still a good year away, in our estimation, from where you can imagine a known financial services company using this,” Ludwin says. “But it’s not 10 years. And when it happens, people will be surprised by how quickly it spreads.”
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
The pipelines were building in spite of poor performance for this year’s high-profile deal from Snap, the owner of Snapchat, in the US and investor concerns that a strengthening euro may curtail the earnings recovery in Europe.
对于英国广播公司文化部门来说，戛纳期间堆满了工作，而派对是少之又少。但是，影展之外的电影节给小镇描上了醉人的红色。在2013年，我们试图联系白雪香槟酒庄（Piper Heidsieck）计算电影节期间香槟的消费数量，但作为提供“官方饮品”的白雪香槟酒庄拒绝回应。不过看看克鲁瓦塞特(Croisette)大道上那些微醺的脸庞以及踉跄的步态，我们可以合理的推测香槟的消费数量十分庞大。电影节的第一周，在为马提欧?加洛尼影片《故事的故事》(Tale of Tales)举办的派对上香槟成河，狂欢者嗨至凌晨。次日早晨，英国广播公司的瑞贝卡?劳伦斯与某位明星进行访谈，询问其在采访前休息了多久。这位明星只是眯起了惺忪的眼睛，抬起了2根手指。
About this collection